How the Adaptyv Foundry works

1. Experiment setup

After you confirm your experiment, our foundry automatically orders all necessary experiment components. Typically we will have everything ready within 2 weeks to start the experiments.

2. Building phase

After all components are ready, we assemble the DNA for your proteins and express them. Our expression systems are optimized to ensure proper protein folding and high yields. Whether you’re working with nanobodies, scFvs, other antibody formats or fully de novo designed proteins - we got you covered!

3. Protein test

We use state-of-the-art instruments for sensing biomolecular interactions. Our assays have been optimized over many iterations to deliver high quality, reproducible data that allows you to make better decisions about how to improve your designs.

4. Data collection and validation

We automatically process and fit your data and generate an interactive report that shows you the most important experiment results at one glance. We handle the data processing for you and show you exactly how your designs performed, including confidence intervals and noise estimates.

Choose experiment type

Protein Binding Screening
Detect whether your proteins bind to a target protein

From

$99/design
3 weeks till results
Protein Affinity Characterization
Quantify the binding strength of your proteins to their targets

From

$149/design
3 weeks till results
Epitope Binning Analysis
Map protein binding sites on your target

From

$39/interaction
3 weeks till results
Thermostability
Measure how stable your proteins are vs heat
Coming soon
Gene Editing Enzymes
Measure how your proteins bind and edit DNA
Coming soon
👀 Looking for something else?
→ Let us know what type of experiment you would need!

Estimate experiment cost

Protein Binding Screening

Our Protein Binding Screening workflow enables users to easily design new protein binders and characterize their interaction to one or several protein targets of interest. The assay is designed to serve as entry point into the discovery process and validation of protein interactions and provides a quick filter to separate promising candidates from other sequences, enabling faster and more targeted assays downstream. The workflow is designed to capture a wide range of molecular interactions ranging from low micromolar (uM) to low picomolar (pM) dissociation constants. This workflow includes the design and synthesis of the DNA coding for your protein, the expression of the protein variants in cell-free and their characterization using our binding screening workflow. You will be able to access the following information for each interaction pair: - Protein Expression and Yield - Binding Strength Rank - Including an estimate of Dissociation Constant (KD) and Kinetic Parameters (Kon and Koff) - Quality Control and confidence level After the workflow is completed, you will be able to explore the data directly in our foundry portal, compare results across experiments and select variants to be characterized on our other available workflows.

Learn more...Assay Visual
Experiment Configuration
$119/design
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+$0/design
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+$48/design
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300 assays (100 designs x 3 replicates)

Target 1

$TBD

Total estimate

$16,700

Turnaround time

3 weeks